here are the best tips i can give (as a colombian) if you are visiting
dont be scared and stop asking if its safe. no place in the world is safe, feed off the energy of where you are (trust me you can tell when its a bad area/neighbourhood)
if you are looking for drugs/prostitutes..sure, just keep in mind the people in this business may look at you as a target and to them you are now vulnerable and easy to rob.
many people wonder why robberies are so common so let me explain that a bit, the minimum wage there is about 350$ USD max. with that being said people do not hesitate to rob you a gold watch, chain, cellphone.. that has value. robbing a 1000$ necklace is almost 3 months work worth to them so you have to look at it like that. keep in mind these people have families to feed too but for you, well its just gold you can probably recover in less than 1 month back home.
be ready to adjust to a more relaxed and slow paced country. we are never in a rush and everything goes with the flow, its just the way it is (dont ask lmao)
pack for every type of weather, if you are going all around the weather will be a bit of everything, so not kidding when i say pack for cold, hot, really hot, rainy, wet, damp.
dont be scared to make local friends BUT be very cautious because everyone is extremely welcoming/friendly/nice and many wont hesitate to take advantage of you.
i can do another post if requested on nightlife there.. REAL tips, not some american BS tips for people that only go to medellin (most tourists spot)