The first time I visited Myanmar was 14 years ago. And I really wanted to come back! So during this trip I spent 3 days in Mandalay, 4 days in Bagan and 3 days in Yangon, and here are some of my thoughts and take aways from this trip:
First of all, I know what you want to ask. And yes, it's safe. I mean, all main tourist destinations are safe. Where it's dangerous, they simply won't let you go. That's why you can't find anyone who'll bring you to the other side of Irrawaddy river: it's not safe. I really wanted to visit Mingun pagoda, but...
Also, a lot of pagodas in Mandalay were affected by the eartquake. And not only pagodas. But there's still a lot to see there.
During the reainy season Myanmar is OK: we enjoyed weather in Mandalay and Bagan, but we were not so lucky in Yangon. It rained every day.
We haven't seen any European face during the most of our trip. There were no tourists in Mandalay and only a couple of Chinese tourists in Bagan. That's why you feel yourself like an Indiana Jones here. Very cool feeling.
Locals are very kind! Very nice, friendly and smiley people. Of course, most of them don't speak English very well, but they are really trying to be helpful.
Yangon is very different from the rest of the country. It's a little bit weird to see expensive fine dining restaurants in a country where most of the population doesn't even use cards...
Oh yeah, few words about bank cards. Don't forget to take cash. It's easy to find ATM in Yangon now, but not in Mandalay or especially Bagan. Most of the shops/hotels doesn't accept cards also. So take your USD (totally new, without any marks!) and change them to Myanmar Kyats.